By Marcus Chown
Stephen Hawking defined it as 'the discovery of the century, if no longer of all time', but the scientists who first detected the cosmic radiation that was once pointed out because the afterglow of the large bang needed to admit that it used to be extra accidentally than purpose. firstly its discoverers mistook the readings for the disruption as a result of the droppings of pigeons that had nested of their telescope, and but they went directly to win the Nobel prize. within the mid-1990s New Scientist author Marcus Chown drove throughout the United States to interview the main scientists who had made this surprising discovery. Their account and Chown's description in their success was once released to a lot acclaim. yet now, over a decade later, during this new and entirely revised variation he is going in the back of the hype and the hysteria to supply a transparent and vigorous clarification of 1 of the most important discoveries in glossy technological know-how - and a super photo of what occurred subsequent.
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5 Recent Advances in Our Understanding of Raft Formation Principles from Model Membrane Studies: Role of Lipid Asymmetry in Domain Formation . . . . . . . . . . . 6 Effect of Sphingolipid Structure on Domain Formation . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 35 36 37 38 39 45 Abstract There is growing evidence that cell membranes can contain domains with different lipid and protein compositions and with different physical properties.
Curr Mol Med 10(5):454–466 Zeidan YH, Wu BX, Jenkins RW, Obeid LM, Hannun YA (2008) A novel role for protein kinase C delta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury. FASEB J 22(1):183–193 Zhang H, Li D, Su Y, Jiang S, Xu Y, Jiang K, Cui D (2012) Identification of the N-acylsphingosine amidohydrolase 1 gene (ASAH1) for susceptibility to schizophrenia in a Han Chinese population. World J Biol Psychiatry 13(2):106–113 Sphingolipids and Membrane Domains: Recent Advances Salvatore Chiantia and Erwin London Contents 1 Membrane Physical State and Membrane Domain Formation .
This suggests that there is some degree of coupling between the inner and outer lipid physical states. However, this interleaflet coupling is not “strong,” as strong coupling would imply that the thermal melting of the bilayer occurs at a Tm that is intermediate between that of the inner and outer leaflet lipids, and this is not what is observed (Cheng and London 2011; Cheng et al. 2009). Instead, the high Tm-lipid-rich leaflet has a Tm similar to that in vesicles composed of pure high Tm lipid.
Afterglow of Creation by Marcus Chown