By Laurent Bracco, Emeline Throo, Olivier Cochet (auth.), Professor Dr. Philippe Jeanteur (eds.)
Splicing of fundamental RNA transcript, i.e. elimination of introns and becoming a member of of exons to provide mature mRNAs useful for translation into proteins, is a quasi-systematic step of gene expression in larger organisms. even if, this technique isn't unequivocal yet can stick with exchange pathways. replacement splicing of a given transcript can hence yield a number of unique mRNAs encoding as many alternative proteins. Its complete organic importance has no longer been favored until eventually it was once famous that replacement splicing is so normal as to impact approximately seventy five% of all human genes. as a result, replacement splicing not just drastically raises protein range but in addition deals a number of possibilities for aberrant splicing occasions with pathological consequences.
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Additional resources for Alternative Splicing and Disease
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Alternative Splicing and Disease by Laurent Bracco, Emeline Throo, Olivier Cochet (auth.), Professor Dr. Philippe Jeanteur (eds.)