Laurent Bracco, Emeline Throo, Olivier Cochet (auth.),'s Alternative Splicing and Disease PDF

By Laurent Bracco, Emeline Throo, Olivier Cochet (auth.), Professor Dr. Philippe Jeanteur (eds.)

ISBN-10: 3540344489

ISBN-13: 9783540344483

ISBN-10: 3540344497

ISBN-13: 9783540344490

Splicing of fundamental RNA transcript, i.e. elimination of introns and becoming a member of of exons to provide mature mRNAs useful for translation into proteins, is a quasi-systematic step of gene expression in larger organisms. even if, this technique isn't unequivocal yet can stick with exchange pathways. replacement splicing of a given transcript can hence yield a number of unique mRNAs encoding as many alternative proteins. Its complete organic importance has no longer been favored until eventually it was once famous that replacement splicing is so normal as to impact approximately seventy five% of all human genes. as a result, replacement splicing not just drastically raises protein range but in addition deals a number of possibilities for aberrant splicing occasions with pathological consequences.

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Neurosci Lett 359: 151–154 Vandenbroucke, II, Vandesompele J, Paepe AD, Messiaen L (2001) Quantification of splice variants using real-time PCR. Nucleic Acids Res 29: E68–68 Veistinen E, Liippo J, Lassila O (2002) Quantification of human Aiolos splice variants by real-time PCR. J Immunol Methods 271: 113–123 Wagner EJ, Curtis ML, Robson ND, Baraniak AP, Eis PS, Garcia-Blanco MA (2003) Quantification of alternatively spliced FGFR2 RNAs using the RNA invasive cleavage assay. Rna 9: 1552–1561 Wang H, Hubbell E, Hu JS, Mei G, Cline M, Lu G, Clark T, Siani-Rose MA, Ares M, Kulp DC, Haussler D (2003) Gene structure-based splice variant deconvolution using a microarray platform.

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Alternative Splicing and Disease by Laurent Bracco, Emeline Throo, Olivier Cochet (auth.), Professor Dr. Philippe Jeanteur (eds.)


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