Laurent Bracco, Emeline Throo, Olivier Cochet (auth.),'s Alternative Splicing and Disease PDF

By Laurent Bracco, Emeline Throo, Olivier Cochet (auth.), Professor Dr. Philippe Jeanteur (eds.)

ISBN-10: 3540344489

ISBN-13: 9783540344483

ISBN-10: 3540344497

ISBN-13: 9783540344490

Splicing of fundamental RNA transcript, i.e. elimination of introns and becoming a member of of exons to provide mature mRNAs useful for translation into proteins, is a quasi-systematic step of gene expression in larger organisms. even if, this technique isn't unequivocal yet can stick with exchange pathways. replacement splicing of a given transcript can hence yield a number of unique mRNAs encoding as many alternative proteins. Its complete organic importance has no longer been favored until eventually it was once famous that replacement splicing is so normal as to impact approximately seventy five% of all human genes. as a result, replacement splicing not just drastically raises protein range but in addition deals a number of possibilities for aberrant splicing occasions with pathological consequences.

Show description

Read Online or Download Alternative Splicing and Disease PDF

Similar nonfiction_9 books

New PDF release: New therapeutic strategies for type 2 diabetes : small

Content material: Preface, kind 2 Diabetes - illness assessment; advertised Small Molecule Dipeptidyl Peptidase IV (DPP4) Inhibitors as a brand new category of Oral Anti-diabetics; SGLT2 Inhibitors in improvement; Glucokinase Activators in improvement; eleven -Hydroxysteroid dehydrogenase variety 1 (11 -HSD1) inhibitors in improvement; contemporary Advances in PTP1B Inhibitor improvement for the therapy of Type-2 Diabetes and weight problems; fresh advances within the discovery of GPR119 agonists; Acyl-CoA:diacylglycerol acyltransferase-1 inhibition as an method of the remedy of variety 2 diabetes; Stearoyl-CoA Desaturase 1 (SCD1) Inhibitors: Bench to Bedside needs to in simple terms struggle through Liver; TGR5 Agonists in improvement; the invention and improvement of MB07803, a moment iteration fructose-1,6-bisphosphatase inhibitor with more suitable pharmacokinetic houses, as a possible remedy of kind 2 diabetes; Inhibition of Glycogen Phosphorylase as a method for the remedy of style 2 Diabetes; SIRT1 Activators in improvement; Long-Chain unfastened Fatty Acid Receptor Agonists; Glucagon Receptor Antagonists in improvement; ACC Inhibitors in improvement; Index

New PDF release: The 2007 ESO Instrument Calibration Workshop: Proceedings of

The 2007 ESO software Calibration workshop introduced jointly greater than one hundred twenty individuals with the target to a) foster the sharing of data, adventure and strategies among observers, software builders and tool operation groups, b) evaluate the particular precision and barriers of the utilized device calibration plans, andc) acquire the present and destiny standards by way of the ESO clients.

New PDF release: Post-Genomic Perspectives in Modeling and Control of

Put up Genomic views in Modeling and keep an eye on of respiring is constituted of the court cases of the IXth Oxford convention on Modeling and regulate of respiring, held September 13-16, 2003 in Paris, France. This ebook is put in the normal framework of post-genomic neurobiology, pathology, and the fitting instance of the rhythmic breathing neural meeting getting used to appreciate how genetic networks were chosen and conserved within the vertebrate mind.

Additional resources for Alternative Splicing and Disease

Sample text

Neurosci Lett 359: 151–154 Vandenbroucke, II, Vandesompele J, Paepe AD, Messiaen L (2001) Quantification of splice variants using real-time PCR. Nucleic Acids Res 29: E68–68 Veistinen E, Liippo J, Lassila O (2002) Quantification of human Aiolos splice variants by real-time PCR. J Immunol Methods 271: 113–123 Wagner EJ, Curtis ML, Robson ND, Baraniak AP, Eis PS, Garcia-Blanco MA (2003) Quantification of alternatively spliced FGFR2 RNAs using the RNA invasive cleavage assay. Rna 9: 1552–1561 Wang H, Hubbell E, Hu JS, Mei G, Cline M, Lu G, Clark T, Siani-Rose MA, Ares M, Kulp DC, Haussler D (2003) Gene structure-based splice variant deconvolution using a microarray platform.

Chembiochem 4: 1120–1128 Wong YW, Sia GM, Too HP (2002) Quantification of mouse glial cell-line derived neurotrophic factor family receptor alpha 2 alternatively spliced isoforms by real time detection PCR using SYBR Green I. Neurosci Lett 320: 141–145 Yeakley JM, Fan JB, Doucet D, Luo L, Wickham E, Ye Z, Chee MS, Fu XD (2002) Profiling alternative splicing on fiber-optic arrays. Nat Biotechnol 20: 353–358 Yeo GW, Van Nostrand E, Holste D, Poggio T, Burge CD (2005) Identification and analysis of alternative splicing events conserved in human and mouse.

Ann Hematol 78: 472–474 Methods and Platforms for the Quantification of Splice Variants 23 Kalbfuss B, Mabon SA, Misteli T (2001) Correction of alternative splicing of tau in frontotemporal dementia and parkinsonism linked to chromosome 17. J Biol Chem 276: 42986–42993 Kampa D, Cheng J, Kapranov P, Yamanaka M, Brubaker S, Cawley S, Drenkow J, Piccolboni A, Bekiranov S, Helt G, Tammana H, Gingeras TR (2004) Novel RNAs identified from an in-depth analysis of the transcriptome of human chromosomes 21 and 22.

Download PDF sample

Alternative Splicing and Disease by Laurent Bracco, Emeline Throo, Olivier Cochet (auth.), Professor Dr. Philippe Jeanteur (eds.)

by Ronald

Rated 4.50 of 5 – based on 21 votes