By V. Stefanovich
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Additional info for Animal Models and Hypoxia. Proceedings of an International Symposium on Animal Models and Hypoxia, Held at Wiesbaden, Federal Republic of Germany, 19 November 1979
The relatively well preserved energy state of the brain in regions in which blood flow was far below the critical threshold for maintenance of tissue integrity is difficult to explain. One factor may be a shutdown of cortical activity, leading to a saving of the energy demands of the tissue (Bito and Myers, 1972). As has been described above, EEG amplitude decreases at substantially higher flow values than those causing a breakdown of energy metabolism, and it is reasonable to assume that with decreased cortical activity the energy requirements of the brain also decrease.
Questions or comments? Vogel: I have a question: You showed very large differences of biochemical parameters in brain due to vincristine. Is this confined only to brain or are other organs like liver, kidneys and so on, influenced in a similar manner? Hoyer: Well, we did not investigate other organs. Our interest is directed towards the brain. But it can be assumed that other organs are influenced, too. Since, if you applicate this vincristine intraperitoneally or subcutaneously, you many observe general and severe disturbances in the animals (which we discarded from this study), and therefore we changed our methods.
It could be found that vincristine inhibits the glycolytic flux by means of inhibiting the flux-controlling enzyme phosphofructokinase. These results are in agreement with findings in patients suffering from Alzheimer's disease in whom a very low phosphofructokinase activity was found. The vincristine model seems to be useful in experimental gerontopsychiatry. KEYWORDS Gerontopsychiatric disorders; brain energy metabolism; phosphofructokinase; vincristine. INTRODUCTION Animal models in experimental medicine should fulfil the condition that they are closely related to human diseases.
Animal Models and Hypoxia. Proceedings of an International Symposium on Animal Models and Hypoxia, Held at Wiesbaden, Federal Republic of Germany, 19 November 1979 by V. Stefanovich